Soft Biopsy Philippines: A Novel Technology for Cervical Lesions

A gentler approach to cervical tissue sampling and evaluation.

Sometimes, further evaluation is needed after cervical cancer screening.

Soft biopsy technology allows tissue sampling in a less invasive and less intimidating way—helping patients move from screening toward diagnosis and treatment planning when necessary.

Early evaluation can help prevent cervical cancer before it advances.

Why Further Evaluation Matters

Cervical cancer screening methods such as:

can identify abnormal or suspicious areas of the cervix.

However, in some patients, a tissue sample may still be needed to:

  • Confirm abnormal findings
  • Evaluate suspicious lesions
  • Guide treatment decisions
  • Rule out more serious disease

Soft Biopsy Philippines: A Less Invasive Way to Collect Cervical Tissue

Unlike traditional punch biopsy devices that cut tissue using sharp metal edges, soft biopsy technology uses a gentle friction-based approach to collect tissue from the surface of abnormal cervical areas.

CerviQ utilizes a disposable soft biopsy tissue collection and transport system designed to:

  • Collect trans-epithelial cervical tissue
  • Reduce discomfort
  • Minimize bleeding
  • Improve patient acceptance

The collected tissue is then preserved and sent to the laboratory for histopathologic evaluation.

How Soft Biopsy is Performed

The device is gently applied over the suspicious cervical area using controlled pressure.

The sampling tip is then rotated over the lesion to collect tissue from the surface layer of the cervix.

Once the sample is obtained:

  • The collection tip is detached
  • Placed into a specimen vial
  • Sent to the pathology laboratory for evaluation

The procedure is commonly performed in an outpatient or clinic setting.

Soft Biopsy Philippines

Soft Biopsy vs Traditional Punch Biopsy

Traditional punch biopsy:

  • Uses a sharp cutting edge
  • Removes a deeper piece of tissue
  • May cause more bleeding or discomfort

Soft biopsy technology:

  • Uses gentle frictional tissue collection
  • Is generally less painful
  • Produces minimal bleeding
  • Is less intimidating for many patients
  • Often does not require anesthesia

👉 The tissue collected can still be processed for laboratory evaluation similar to conventional biopsy samples.

FeatureFrictional Biopsy (Soft Brush)Standard / Traditional Biopsy
Tool UsedRotating fabric, Velcro-like soft micro-brushSharp metal forceps or punch tools
Procedure & ComfortLess painful (VAS pain score of about 0-2/10); causes minimal bleedingNoticeably more uncomfortable or painful; may require a local anesthetic
Tissue CollectionExcellent at gathering endocervical cells for analysisCan occasionally crush tissue or fail to collect enough cells
Inadequate Specimen RateVery low (approx. 0.6%)Higher rate of inadequate samples (approx. 4.2%)
Soft Biopsy Philippines

A standard cervical punch biopsy device  used to remove a small tissue sample from the cervix for laboratory examination.

Soft Biopsy Philippines

          Kylon®  is  a  hooked  nylon  fabric  tissue  collection  system  that  can  be mounted  to  the   applicator  stick,  that  when  pressed  on  tissue  surfaces, allows  the  hook  tip  to  contact  the   target  tissues,  and  with  pressure and  rotation,  a  trans-­‐epithelial  biopsy  is  obtained  and   stored  for transport  to  the  lab  (Figure  1).

          The  procedure  of  applying,  pressing, and  rotating   a  Kylon®  covered device  onto  the  surface  of  the  lower gential  tract  or  cervical  tissue  with  moderate  pressure and rotating it to obtain a  biopsy specimen is called a SOFT BIOPSY@ (Figure 2.)

Who May Benefit From Soft Biopsy?

Recommendations

Soft biopsy may be considered for patients with:

    • VIA-positive lesions
    • HPV-positive findings
    • Suspicious cervical changes
    • Unsatisfactory or unclear cervical images
    • Patients needing tissue evaluation before treatment
    • Patients hesitant to undergo traditional punch biopsy

Understanding the Limitations

Soft biopsy technology is designed to collect surface (trans-epithelial) tissue samples.

Because it does not obtain deep tissue architecture:

    • It may not fully evaluate invasive or micro-invasive cancer
    • Additional punch biopsy or surgical biopsy may still be required in selected patients
    • Interpretation depends on the lesion and clinical situation

Some samples may also appear fragmented during pathology review.

👉 If invasive cancer is suspected, referral for further evaluation is necessary.

Contraindications

Soft biopsy may not be appropriate in patients with:

    • Bleeding disorders
    • Anticoagulant therapy
    • Suspected cervicitis or active infection
    • Known allergy to nylon or acrylic plastics
    • Pregnancy or suspected pregnancy when cervical biopsy is not indicated

What to Expect During and After the Procedure

Most patients report:

    • Very minimal discomfort
    • Very little bleeding or spotting
    • Fast recovery
    • Low anxiety compared with traditional biopsy

Most women can resume normal light activities shortly after the procedure.

Depending on the doctor’s assessment:

    • Mild pain relievers
    • Tranexamic acid (if bleeding occurs)
    • Antibiotics in selected cases

may sometimes be prescribed.

Frequently Asked Questions

Most patients report very minimal pain or discomfort during soft biopsy compared with traditional punch biopsy.

In many cases, anesthesia is not required.

A biopsy helps confirm abnormal findings and guides the next step in treatment or follow-up.

Not necessarily. Many biopsies show pre-cancerous or treatable changes rather than invasive cancer.

The tissue sample will be sent to the laboratory for analysis. Your doctor will discuss the results and recommend the next steps.

Results may show:

Depending on the findings, management may include:

    • Follow-up monitoring
    • Thermal ablation
    • Further biopsy or LEEP
    • Referral to a specialist or gynecologic oncologist
HPV Vaccination Philippines UCSD + CerviQ research collaboration immersion Day 2 at Mother Therese Mother’s Clinic in Baliwag, Bulacan

CALL TO ACTION

Bring Advanced Cervical Evaluation Closer to Communities

CerviQ supports:

    • LGU screening systems
    • Diagnostic pathways
    • Referral coordination
    • Training and implementation support

Early Evaluation Helps Prevent Advanced Disease

👉 Book a cervical cancer screening and evaluation
👉 Learn whether further testing or treatment is needed